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Claude Skills by AlterLab-IEU
github.com/AlterLab-IEU346 skills4 installs520 views
- Alterlab Thesis SupervisorSupervises theses and dissertations end to end — structure guidance from proposal through defense, chapter-by-chapter writing support (introduction, literature review, methodology, results, discussion), supervision strategies, committee management, defense and viva voce preparation, timeline planning, feedback integration, examiner-expectation guidance, and formatting (APA 7, Chicago, university styles). Use when the request mentions thesis, dissertation, supervision, defense preparation, viv...Votes: 0GitHub stars: 68
- Alterlab DaskScales pandas/NumPy workflows beyond memory with Dask distributed computing — parallel DataFrames, arrays, delayed task graphs, and cluster execution. Use when existing pandas/NumPy code must run on larger-than-RAM data or across clusters, for parallel file processing, distributed ML, or integration with existing pandas code. For out-of-core analytics on a single machine prefer vaex; for in-memory speed prefer polars. Part of the AlterLab Academic Skills suite.Votes: 0GitHub stars: 68
- Alterlab EdaExploratory data analysis (EDA) on a scientific data file — auto-detects the format, runs structure/quality/statistics checks, and writes a markdown EDA report with downstream recommendations. Use when asked to "explore", "analyze", "summarize", "profile", or "QC" a data file, or to understand its structure/content/quality before deciding what analysis to run. Covers tabular (.csv .tsv .xlsx .parquet), arrays (.npy .npz .hdf5 .h5 .mat .fits), sequence/genomics (.fasta .fastq .sam .bam .vcf .b...Votes: 0GitHub stars: 68
- Alterlab NetworkxCreates, analyzes, and visualizes complex networks and graphs in Python with NetworkX. Use when working with network/graph data structures, analyzing relationships between entities, computing graph algorithms (shortest paths, centrality, clustering), detecting communities, generating synthetic networks, or visualizing topologies — applicable to social, biological, transportation, citation, and any pairwise-relationship networks. This is classical graph analytics, not deep learning — for train...Votes: 0GitHub stars: 68
- Alterlab PolarsFast in-memory DataFrame analytics with Polars — lazy evaluation, parallel execution, and an Apache Arrow backend for datasets that fit in RAM. Use when pandas is too slow but data still fits in memory, for 1-100GB datasets, ETL pipelines, or a faster pandas replacement. For larger-than-RAM data prefer dask or vaex. Part of the AlterLab Academic Skills suite.Votes: 0GitHub stars: 68
- Alterlab PufferlibScales reinforcement learning with PufferLib — high-throughput parallel training (PuffeRL), vectorized environments, and native multi-agent systems achieving 2-10x speedups over standard implementations. Use when scaling RL to millions of steps per second, running vectorized or multi-agent setups, building custom PufferEnv tasks, or integrating game environments (Atari, Procgen, NetHack, PettingZoo). For standard single-agent algorithm implementations (PPO/SAC/DQN) or quick prototyping prefer...Votes: 0GitHub stars: 68
- Alterlab PymcBayesian modeling and probabilistic programming with PyMC 6 and ArviZ 1.x — hierarchical models, MCMC (NUTS via PyMC, nutpie, NumPyro, or BlackJAX), variational inference, PSIS-LOO model comparison, and prior/posterior predictive checks. Use when fitting Bayesian or hierarchical models, estimating posteriors and credible intervals, diagnosing divergences, R-hat, or ESS, running probabilistic inference, or comparing models with LOO (WAIC was removed from ArviZ 1.x). Part of the AlterLab Academ...Votes: 0GitHub stars: 68
- Alterlab PymooMulti-objective optimization with pymoo — NSGA-II, NSGA-III, MOEA/D, Pareto-front computation, constraint handling, and standard benchmarks (ZDT, DTLZ). Use when solving multi-objective or constrained optimization problems, computing Pareto-optimal trade-offs, or tackling engineering design problems with competing objectives. Part of the AlterLab Academic Skills suite.Votes: 0GitHub stars: 68
- Alterlab Pytorch LightningScalable deep-learning training with PyTorch Lightning — organize PyTorch code into LightningModules, configure Trainers for multi-GPU/TPU, build data pipelines and callbacks, log to W&B or TensorBoard, and run distributed training (DDP, FSDP, DeepSpeed). Use when structuring PyTorch training loops, scaling neural-network training across GPUs/TPUs, or adding checkpointing, logging, and distributed strategies. Part of the AlterLab Academic Skills suite.Votes: 0GitHub stars: 68
- Alterlab Scikit LearnClassical machine learning in Python with scikit-learn — algorithms, preprocessing, pipelines, and best-practice reference documentation. Use when working with supervised learning (classification, regression), unsupervised learning (clustering, dimensionality reduction), model evaluation, hyperparameter tuning, feature preprocessing, or building ML pipelines. Part of the AlterLab Academic Skills suite.Votes: 0GitHub stars: 68
- Alterlab Scikit SurvivalSurvival analysis and time-to-event modeling in Python with scikit-survival. Use when working with censored survival data, fitting Cox models, Random Survival Forests, Gradient Boosting models, or Survival SVMs, evaluating predictions with concordance index or Brier score, handling competing risks, or implementing any time-to-event workflow. Part of the AlterLab Academic Skills suite.Votes: 0GitHub stars: 68
- Alterlab ShapModel interpretability and explainability with SHAP (SHapley Additive exPlanations) — feature importance and plots (waterfall, beeswarm, bar, scatter, force, heatmap). Use when explaining ML model predictions, computing feature importance, debugging models, analyzing bias or fairness, comparing models, or implementing explainable AI across tree-based models (XGBoost, LightGBM, Random Forest), deep learning (TensorFlow, PyTorch), linear models, and any black-box model. Part of the AlterLab Aca...Votes: 0GitHub stars: 68
- Alterlab SimpyProcess-based discrete-event simulation in Python with SimPy — processes, queues, shared resources, and time-based events. Use when simulating systems where entities contend for shared resources over time, such as manufacturing systems, service operations, network traffic, or logistics. Part of the AlterLab Academic Skills suite.Votes: 0GitHub stars: 68
- Alterlab Stable Baselines3Trains single-agent reinforcement learning agents with Stable-Baselines3 — PPO, SAC, DQN, TD3, DDPG, and A2C behind a scikit-learn-like API. Use for standard single-agent RL experiments, quick prototyping, well-documented algorithm implementations on Gymnasium environments, or adding callbacks and evaluation. For high-throughput parallel training, multi-agent systems, or custom vectorized environments prefer alterlab-pufferlib. Part of the AlterLab Academic Skills suite.Votes: 0GitHub stars: 68
- Alterlab Statistical AnalysisGuided statistical analysis with hypothesis-test selection, assumption checking, effect sizes, power analysis, and APA-formatted reporting using scipy.stats, statsmodels, and pingouin (Bayesian alternatives with PyMC). Use when choosing and running the appropriate statistical test for data, verifying test assumptions, computing power/sample size, or producing APA-style results for academic research. For implementing specific models programmatically prefer alterlab-statsmodels. Part of the Alt...Votes: 0GitHub stars: 68
- Alterlab StatsmodelsStatistical modeling in Python with statsmodels — OLS/WLS/GLS, GLM, discrete-choice and count models, mixed models, ARIMA/SARIMAX/VAR, with diagnostics, robust standard errors, and coefficient-level inference. Use when fitting specific model classes for econometrics, time series, or rigorous inference with coefficient tables and confidence intervals, or when updating code for statsmodels 0.15 (result_object named results, rng keyword). For guided statistical test selection with APA reporting ...Votes: 0GitHub stars: 68
- Alterlab SympySymbolic mathematics in Python with SymPy — solve equations algebraically, perform calculus (derivatives, integrals, limits), manipulate algebraic expressions, work with symbolic matrices, and generate executable code from formulas. Use when exact symbolic results are needed rather than numerical approximations, or for physics, number-theory, and geometry computations involving variables and parameters. Part of the AlterLab Academic Skills suite.Votes: 0GitHub stars: 68
- Alterlab TimesfmForecasts time series zero-shot with Google's TimesFM foundation models — TimesFM 2.5 (200M, Apache-2.0 weights; ForecastConfig API, XReg covariates) and TimesFM 3.0 (~330M, multivariate with native past/future covariates; non-commercial weights) — producing point forecasts and quantile prediction intervals from CSV/DataFrame/array inputs, with a preflight system checker for RAM/GPU. Use when forecasting univariate or multivariate series (sales, sensors, energy, vitals, weather) without train...Votes: 0GitHub stars: 68
- Alterlab Torch GeometricGraph Neural Networks with PyTorch Geometric (PyG) — node and graph classification, link prediction, GCN, GAT, and GraphSAGE layers, heterogeneous graphs, and molecular property prediction. Use when building or training GNNs for geometric deep learning on graph-structured data. Part of the AlterLab Academic Skills suite.Votes: 0GitHub stars: 68
- Alterlab TransformersLoads, runs, and fine-tunes pretrained models with Hugging Face Transformers v5 (PyTorch-only) — pipeline() inference for chat-model text generation, text classification, NER, zero-shot, speech recognition, image classification, object detection, and image-text-to-text VLMs; AutoModel/AutoTokenizer loading with dtype, device_map and bitsandbytes quantization; generate() decoding control; and Trainer fine-tuning with optional PEFT/LoRA. Use when running inference with a Hugging Face Hub checkp...Votes: 0GitHub stars: 68
- Alterlab UmapNonlinear dimensionality reduction with UMAP — fast manifold learning for 2D/3D visualization, clustering preprocessing (e.g., HDBSCAN), and supervised or parametric UMAP. Use when projecting high-dimensional data to low dimensions for visualization, embedding generation, or as a preprocessing step before clustering. Part of the AlterLab Academic Skills suite.Votes: 0GitHub stars: 68
- Alterlab VaexOut-of-core tabular analytics with Vaex — memory-mapped HDF5/Arrow/Parquet via vaex.open, lazy virtual columns, delayed single-pass aggregations on billion-row tables, binned histograms/heatmaps, and vaex.ml transformers on one machine. Vaex is in minimal-maintenance mode (vaex-core 4.19 from Sep 2025 supports only Python 3.9–3.12 and pandas < 3), so use it to run, fix, or migrate existing Vaex code; for new larger-than-RAM work prefer Polars lazy/streaming queries (alterlab-polars) or Dask (...Votes: 0GitHub stars: 68
- Alterlab ZarrChunked, compressed N-dimensional arrays for cloud storage with Zarr — parallel I/O, S3/GCS integration, and NumPy/Dask/Xarray compatibility. Use when storing or reading large N-D scientific arrays, streaming chunked data to/from cloud object stores, or building large-scale scientific computing pipelines. Part of the AlterLab Academic Skills suite.Votes: 0GitHub stars: 68
- Alterlab Alphafold DbAccess the AlphaFold DB of 240M+ AI-PREDICTED protein structures (v6, plus precomputed homodimer/heterodimer complexes) — retrieve models by UniProt accession, download PDB/mmCIF files, and analyze prediction confidence metrics (pLDDT, PAE). Use when a UniProt ID needs a computationally predicted 3D structure or when no experimental structure exists, for homology modeling, protein engineering, or structure-based drug discovery; for EXPERIMENTALLY determined structures (X-ray, cryo-EM, NMR) pr...Votes: 0GitHub stars: 68
- Alterlab ArxivSearch and retrieve preprints from arXiv via the Atom API by keywords, authors, arXiv IDs, date ranges, or subject categories. Use when finding or fetching papers in physics, mathematics, computer science, quantitative biology, quantitative finance, statistics, electrical engineering, or economics, or resolving an arXiv ID to its metadata and PDF. Part of the AlterLab Academic Skills suite.Votes: 0GitHub stars: 68
- Alterlab BindingdbQuery BindingDB for measured protein-ligand binding affinities (Ki, Kd, IC50, EC50) via its keyless REST API or the full TSV download, searching by target (UniProt ID), compound (SMILES), or pathogen. Use when looking up experimental binding constants, profiling inhibitors of a protein target, doing lead optimization, polypharmacology analysis, or structure-activity relationship (SAR) studies; for curated bioactivity mining or drug-like compound library screening at scale prefer alterlab-chem...Votes: 0GitHub stars: 68
- Alterlab BiorxivSearch the bioRxiv preprint server and retrieve paper metadata or download PDFs via its API. Use when finding life sciences preprints by keywords, authors, DOI, date ranges, or categories, or when conducting a biology literature review of not-yet-peer-reviewed work. Part of the AlterLab Academic Skills suite.Votes: 0GitHub stars: 68
- Alterlab BrendaAccess the BRENDA enzyme database via its SOAP API to retrieve kinetic parameters (Km, kcat, Ki), reaction equations, organism data, and substrate-specific enzyme information indexed by EC number. Use when looking up enzyme kinetics, turnover numbers, or substrate specificity for biochemical research and metabolic pathway analysis. Part of the AlterLab Academic Skills suite.Votes: 0GitHub stars: 68
- Alterlab CbioportalQuery cBioPortal via its keyless REST API for cancer genomics across TCGA, GENIE, MSK-IMPACT and hundreds of studies — somatic mutations, copy-number alterations (GISTIC), mRNA/protein expression, structural variants, and patient-level clinical/survival data. Use when asked how often a gene is mutated/amplified/deleted in a tumor type, to profile oncogenes or tumor suppressors across cancers (pan-cancer alteration frequency), to pull patient-level mutations joined to OS/clinical outcomes, or ...Votes: 0GitHub stars: 68
- Alterlab ChemblQuery ChEMBL via the chembl_webresource_client Python client for curated bioactive molecules and drug-like compound libraries at scale — search compounds by structure or physicochemical properties, retrieve bioactivity measurements (IC50, Ki, EC50), and find inhibitors of a target. Use when screening chemical libraries, mining curated bioactivity for a protein, running SAR studies, or sourcing medicinal-chemistry data; for measured protein-ligand binding affinities (Ki/Kd/IC50) prefer alterla...Votes: 0GitHub stars: 68
- Alterlab ClinicaltrialsQuery ClinicalTrials.gov via its API v2 to search trials by condition, drug, location, recruitment status, or phase and retrieve trial details by NCT ID. Use when finding interventional or observational studies, checking trial status and eligibility for patient matching, or exporting clinical trial records for research. Part of the AlterLab Academic Skills suite.Votes: 0GitHub stars: 68
- Alterlab ClinpgxAccess ClinPGx pharmacogenomics data (the successor to PharmGKB) to query gene-drug interactions, CPIC/DPWG dosing guidelines, drug labels, and pharmacogene records. Use when interpreting pharmacogenes (CYP2D6, CYP2C19, TPMT, DPYD, SLCO1B1), looking up genotype-guided drug dosing, checking PGx drug-safety associations (e.g. HLA-B*57:01 and abacavir), or supporting precision medicine and clinical pharmacogenomics decisions. For star-allele definitions/frequencies see PharmVar; for germline/som...Votes: 0GitHub stars: 68
- Alterlab ClinvarQuery NCBI ClinVar via the E-utilities API or FTP for the clinical significance (pathogenicity) of human germline genetic variants, searching by gene, variant, condition, or genomic position and interpreting ACMG/AMP classifications and review-status star ratings. Use when assessing whether a variant is pathogenic, likely pathogenic, VUS, likely benign, or benign, resolving conflicting interpretations, or annotating a VCF with ClinVar clinical significance. For population allele frequencies b...Votes: 0GitHub stars: 68
- Alterlab CosmicAccess the COSMIC catalogue of somatic mutations in cancer to query somatic mutations, the Cancer Gene Census, mutational signatures, and gene fusions (authentication required). Use when curating known cancer driver genes, looking up recurrent somatic mutations in a gene, or interpreting mutational signatures for cancer research and precision oncology. Not for germline pathogenicity calls (use alterlab-clinvar) or interactive cohort visualization like OncoPrints and survival from study data (...Votes: 0GitHub stars: 68
- Alterlab DatacommonsQuery Google Data Commons for public statistical data aggregated from global sources, resolving geographic entities and pulling time-series statistics. Use when working with demographic data, economic indicators, health statistics, or environmental data — population counts, GDP figures, unemployment rates, disease prevalence — or when resolving places to DCIDs and exploring relationships between statistical entities. Part of the AlterLab Academic Skills suite.Votes: 0GitHub stars: 68
- Alterlab DepmapQuery the Cancer Dependency Map (DepMap) for cancer cell line gene dependency scores (CRISPR Chronos), drug sensitivity data, and gene effect profiles. Use when identifying cancer-specific genetic vulnerabilities, finding synthetic lethal interactions, checking whether a gene is essential in given cell lines, or validating oncology drug targets. Part of the AlterLab Academic Skills suite.Votes: 0GitHub stars: 68
- Alterlab DrugbankAccess and analyze drug information from the DrugBank database — drug properties, interactions, targets, pathways, chemical structures, and pharmacology data. Use when working with pharmaceutical data, drug discovery research, drug-drug interaction analysis, target identification, chemical similarity searches, ADMET predictions, or any task needing detailed drug and drug-target records from DrugBank. Part of the AlterLab Academic Skills suite.Votes: 0GitHub stars: 68
- Alterlab EnaAccess the European Nucleotide Archive (ENA) via its API and FTP to retrieve DNA/RNA sequences, raw sequencing reads (FASTQ), and genome assemblies by accession, with support for multiple formats. Use when downloading reads or sequences for a study, run, or sample accession, or when sourcing nucleotide data for genomics and bioinformatics pipelines. Part of the AlterLab Academic Skills suite.Votes: 0GitHub stars: 68
- Alterlab EnsemblQuery the Ensembl genome database REST API across 250+ species for gene lookups, sequence retrieval, variant analysis, comparative genomics, orthologs, and Variant Effect Predictor (VEP) annotations. Use when mapping gene IDs or coordinates, fetching genomic sequence, finding orthologs across species, or predicting variant consequences for genomic research. Part of the AlterLab Academic Skills suite.Votes: 0GitHub stars: 68
- Alterlab FdaQuery the openFDA API for drugs, medical devices, adverse event reports, recalls, regulatory submissions (510k, PMA), and substance identification (UNII). Use when searching FDA safety data, pharmacovigilance and adverse-event signals, device clearances, drug labels, or recall records for regulatory data analysis and safety research. Part of the AlterLab Academic Skills suite.Votes: 0GitHub stars: 68
- Alterlab Gene DbQuery NCBI Gene via the E-utilities and Datasets APIs, searching by gene symbol or Gene ID and retrieving gene information (RefSeqs, GO terms, genomic locations, associated phenotypes) including batch lookups. Use when resolving gene symbols to IDs, annotating gene lists, or pulling functional and positional gene metadata for downstream analysis. Part of the AlterLab Academic Skills suite.Votes: 0GitHub stars: 68
- Alterlab GeoAccess NCBI GEO (Gene Expression Omnibus) for gene expression and functional genomics data — search and download microarray and RNA-seq datasets by GSE, GSM, GPL, or GDS accession and retrieve SOFT, MINiML, and series matrix files. Use when locating public expression datasets, fetching processed expression matrices, downloading a study's supplementary files, or sourcing per-study transcriptomics data for differential-expression analysis. For raw FASTQ sequencing reads by SRA/ENA run accession...Votes: 0GitHub stars: 68
- Alterlab GnomadQuery gnomAD (Genome Aggregation Database) for population allele frequencies and gene constraint scores (pLI, LOEUF) reflecting loss-of-function intolerance. Use when checking how common a variant is across populations, filtering rare-disease candidate variants, assessing variant pathogenicity, or identifying loss-of-function intolerant genes. Part of the AlterLab Academic Skills suite.Votes: 0GitHub stars: 68
- Alterlab GtexQuery the GTEx (Genotype-Tissue Expression) portal v2 REST API for tissue-specific gene expression (median TPM across 54 human tissues), expression QTLs (eQTLs), and splicing QTLs (sQTLs). Use when checking which tissues express a gene, finding which gene a non-coding/GWAS variant regulates via eQTLs, or interpreting variant regulatory effects across tissues. NOT for curated trait-variant associations (use alterlab-gwas), population allele frequencies or variant constraint (use alterlab-gnoma...Votes: 0GitHub stars: 68
- Alterlab GwasQuery the NHGRI-EBI GWAS Catalog REST API v2 for curated SNP-trait associations, retrieving variants by rs ID, disease/trait (EFO/MONDO), gene, or study (GCST) with p-values, effect sizes, and ancestry, and locate full harmonised summary statistics on the FTP site. Use when investigating genome-wide association study hits, mapping a SNP or rsID to traits, selecting GWAS for polygenic risk scores or fine-mapping, or doing genetic epidemiology lookups. Part of the AlterLab Academic Skills suite.Votes: 0GitHub stars: 68
- Alterlab HmdbAccess the Human Metabolome Database (HMDB, 220K+ metabolites), searching by name, HMDB ID, or structure to retrieve chemical properties, biomarker data, NMR/MS reference spectra, and associated pathways. Use when identifying a human metabolite, looking up its biomarker or disease associations, matching NMR/MS spectra, or running metabolomics annotation. Part of the AlterLab Academic Skills suite.Votes: 0GitHub stars: 68
- Alterlab Imaging Data CommonsQuery and download public cancer imaging data from the NCI Imaging Data Commons (IDC) using the idc-index Python package, filtering by metadata, visualizing in-browser, and checking licenses, with no authentication required. Use when obtaining large-scale radiology (CT, MR, PET) or digital pathology DICOM datasets for AI/ML training or cancer imaging research. Part of the AlterLab Academic Skills suite.Votes: 0GitHub stars: 68
- Alterlab InterproQuery the EMBL-EBI InterPro REST API for protein family, domain, and functional-site annotations integrated from member databases (Pfam, PANTHER, PRINTS, SMART, SUPERFAMILY, CDD, ProSite, NCBIfam, and others). Use when predicting protein function, analyzing or comparing domain architecture, classifying a protein by family or homologous superfamily, resolving a Pfam/InterPro accession, or mapping a protein's signatures to GO terms. Not for raw UniProt entry/FASTA retrieval or AlphaFold 3D stru...Votes: 0GitHub stars: 68
- Alterlab JasparQuery JASPAR for transcription factor binding site (TFBS) profiles (PWMs/PFMs), searching by TF name, species, or class, scanning DNA sequences for binding sites, and comparing matrices. Use when doing motif analysis, regulatory genomics, transcription factor binding prediction, or interpreting regulatory/non-coding GWAS variants. Part of the AlterLab Academic Skills suite.Votes: 0GitHub stars: 68
- Alterlab KeggProvide direct REST API access to KEGG (academic use only) for pathway analysis, gene-to-pathway and compound-to-pathway mapping, metabolic reactions, KEGG Orthology (KO), drug-drug interactions, and ID conversion. Use when querying KEGG pathways, mapping genes/compounds to metabolic maps, or running KEGG pathway enrichment via raw HTTP/REST; for protein-protein interaction networks prefer alterlab-string-db, for protein sequences and annotations prefer alterlab-uniprot, and for Python workfl...Votes: 0GitHub stars: 68