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Claude Skills by FridrichMethod
github.com/FridrichMethod743 skills4 installs957 views
- Uniprot DatabaseAccess protein metadata, function, taxonomy, and sequences across UniProtKB, UniParc, and UniRef. Use when searching for proteins, mapping identifiers, or retrieving functional annotations and publications. Don't use for sequence alignment, protein folding, or sequence similarity search (use specialized skills for those tasks).Votes: 0GitHub stars: 13
- Unity Ecs PatternsMaster Unity ECS (Entity Component System) with DOTS, Jobs, and Burst for high-performance game development. Use when building data-oriented games, optimizing performance, or working with large entity counts.Votes: 0GitHub stars: 13
- Universal Single Cell AnnotatorAnnotate scRNA-seqVotes: 0GitHub stars: 13
- Using SuperjawnEstablishes how to find and use skills, requiring Skill tool invocation before any response. Use when starting any conversation.Votes: 0GitHub stars: 13
- Uv Package ManagerMaster the uv package manager for fast Python dependency management, virtual environments, and modern Python project workflows. Use when setting up Python projects, managing dependencies, or optimizing Python development workflows with uv.Votes: 0GitHub stars: 13
- UvChecks whether the uv Python package manager is installed and installs it if missing. Ensures uv is on PATH. Use when another skill requires uv as a prerequisite.Votes: 0GitHub stars: 13
- Vaex DataframesOut-of-core DataFrame for billion-row data via lazy evaluation and memory-mapped files. Use when data exceeds RAM (10 GB–TB) for fast aggregation, filtering, virtual columns, and visualization without loading. Supports HDF5, Arrow, Parquet, CSV with cloud (S3, GCS, Azure). Built-in ML transformers (scaling, PCA, K-means). In-memory: polars; distributed: dask.Votes: 0GitHub stars: 13
- Varcadd PathogenicityVariant ScorerVotes: 0GitHub stars: 13
- Variant Interpretation AcmgClassifies genetic variants according to ACMG (American College of Medical Genetics) guidelines.Votes: 0GitHub stars: 13
- Clinical InterpretationClinical variant interpretation using ClinVar, ACMG guidelines, and pathogenicity predictors. Prioritize variants for diagnostic and research applications. Use when interpreting clinical significance of variants.Votes: 0GitHub stars: 13
- Consensus SequencesGenerate consensus FASTA sequences by applying VCF variants to a reference using bcftools consensus. Use when creating sample-specific reference sequences or reconstructing haplotypes.Votes: 0GitHub stars: 13
- DeepvariantDeep learning-based variant calling with Google DeepVariant. Provides high accuracy for germline SNPs and indels from Illumina, PacBio, and ONT data. Use when calling variants with DeepVariant deep learning caller.Votes: 0GitHub stars: 13
- Filtering Best PracticesComprehensive variant filtering including GATK VQSR, hard filters, bcftools expressions, and quality metric interpretation for SNPs and indels. Use when filtering variants using GATK best practices.Votes: 0GitHub stars: 13
- Gatk Variant CallingVariant calling with GATK HaplotypeCaller following best practices. Covers germline SNP/indel calling, GVCF workflow for cohorts, joint genotyping, and variant quality score recalibration (VQSR). Use when calling variants with GATK HaplotypeCaller.Votes: 0GitHub stars: 13
- Joint CallingJoint genotype calling across multiple samples using GATK CombineGVCFs and GenotypeGVCFs. Essential for cohort studies, population genetics, and leveraging VQSR. Use when performing joint genotyping across multiple samples.Votes: 0GitHub stars: 13
- Structural Variant CallingCall structural variants (SVs) from short-read sequencing using Manta, Delly, and LUMPY. Detects deletions, insertions, inversions, duplications, and translocations that are too large for standard SNV callers. Use when detecting structural variants from short-read data.Votes: 0GitHub stars: 13
- Variant AnnotationComprehensive variant annotation using bcftools annotate/csq, VEP, SnpEff, and ANNOVAR. Add database annotations, predict functional consequences, and assess clinical significance. Use when annotating variants with functional and clinical information.Votes: 0GitHub stars: 13
- Variant CallingCall SNPs and indels from aligned reads using bcftools mpileup and call. Use when detecting variants from BAM files or generating VCF from alignments.Votes: 0GitHub stars: 13
- Variant NormalizationNormalize indel representation and split multiallelic variants using bcftools norm. Use when comparing variants from different callers or preparing VCF for downstream analysis.Votes: 0GitHub stars: 13
- Vcf BasicsView, query, and understand VCF/BCF variant files using bcftools and cyvcf2. Use when inspecting variants, extracting specific fields, or understanding VCF format structure.Votes: 0GitHub stars: 13
- Vcf ManipulationMerge, concatenate, sort, intersect, and subset VCF files using bcftools. Use when combining variant files, comparing call sets, or restructuring VCF data.Votes: 0GitHub stars: 13
- Vcf StatisticsGenerate variant statistics, sample concordance, and quality metrics using bcftools stats and gtcheck. Use when evaluating variant quality, comparing samples, or summarizing VCF contents.Votes: 0GitHub stars: 13
- Variant PrioritizationPrioritizes rare-disease variants from trio/quad WES/WGS with de novo (DeNovoGear, Triodenovo), compound-heterozygous phasing (WhatsHap), mosaic VAF tiering, phenotype-driven ranking (Exomiser, Phen2Gene, AMELIE), ClinGen gene-disease validity gating, and ACMG SF v3.2 secondary findings reporting. Use when running diagnostic exome / genome pipelines, identifying candidate Mendelian disease genes, screening for incidental findings, or auditing VUS reclassification cycles. The ACMG/AMP classifi...Votes: 0GitHub stars: 13
- Variant SurveillanceAssigns pathogen lineages (SARS-CoV-2 Pangolin UShER mode; Nextclade clade + QC; pango-designation alias resolution) and tracks variant frequencies over time using Nextstrain (Augur + Auspice), wastewater deconvolution (Freyja, COJAC, alcov, lineagespot), lineage-fitness modelling (multinomial logistic), and recombinant detection (3SEQ, RDP4, Bolotie). Covers Pangolin pangolin-data and Nextclade dataset version pinning (mandatory; lineage-defining mutations change with dataset), Freyja barcod...Votes: 0GitHub stars: 13
- Vector Index TuningOptimize vector index performance for latency, recall, and memory. Use when tuning HNSW parameters, selecting quantization strategies, or scaling vector search infrastructure.Votes: 0GitHub stars: 13
- Vibe CodingAI-assisted coding with Claude Code, Cursor, Copilot, Codex, Aider, or Windsurf. Use to build or debug generated code.Votes: 0GitHub stars: 13
- Virtual Lab AgentAI-powered virtual laboratory orchestrating multi-agent scientific research teams for autonomous hypothesis generation, experimental design, and validation in biomedical research.Votes: 0GitHub stars: 13
- Virtual ScreeningPerforms structure-based virtual screening using AutoDock Vina, SMINA, GNINA (CNN scoring), and DiffDock-L hybrid workflows with explicit choice rules across rigid vs flexible docking, cross-docking vs self-docking, binding-site detection (P2Rank, fpocket), receptor preparation (PDB2PQR, PROPKA), ligand preparation (meeko, OpenBabel), and ultralarge-library screening (ZINC22, Enamine REAL). Use when screening chemical libraries against a protein target to find candidate binders, ranking docki...Votes: 0GitHub stars: 13
- Visual Design FoundationsApply typography, color theory, spacing systems, and iconography principles to create cohesive visual designs. Use when establishing design tokens, building style guides, or improving visual hierarchy and consistency.Votes: 0GitHub stars: 13
- Visual Edit PrecisionUse when making UI/frontend changes guided by visual context, when the user selects elements visually, draws annotations, or provides screenshots alongside change requests. Also use when editing components where spatial context (element identity, DOM references, layout data) supplements text instructions.Votes: 0GitHub stars: 13
- Visual ExplainerHTML explainers, diagrams, architecture, timelines, source maps, slide decks, comparison tables, recaps, plan and diff reviews.Votes: 0GitHub stars: 13
- Volcano CustomizationCreate publication-ready volcano plots with custom thresholds, gene labels, and highlighting using ggplot2, EnhancedVolcano, or matplotlib. Use when visualizing differential expression or association results with gene annotations.Votes: 0GitHub stars: 13
- Wearable Analysis AgentAnalyzes longitudinal wearable sensor data (heart rate, activity, sleep) to detect anomalies and provide personalized health insights.Votes: 0GitHub stars: 13
- Web ArchivingWeb archiving and retrieval via Wayback Machine and Archive.today. Use to preserve content, reach dead pages, or save evidence.Votes: 0GitHub stars: 13
- Web Component DesignMaster React, Vue, and Svelte component patterns including CSS-in-JS, composition strategies, and reusable component architecture. Use when building UI component libraries, designing component APIs, or implementing frontend design systems.Votes: 0GitHub stars: 13
- Web ScrapingAuthorized web scraping with fallback cascades and access-failure handling. Use for social media, yt-dlp, CAPTCHA or 403 blocks.Votes: 0GitHub stars: 13
- Web Ui Best PracticesSigns of taste in web UI. Use when building or reviewing web interfaces, dashboards, SaaS apps, or internal tools.Votes: 0GitHub stars: 13
- Web3 TestingTest smart contracts comprehensively using Hardhat and Foundry with unit tests, integration tests, and mainnet forking. Use when testing Solidity contracts, setting up blockchain test suites, or validating DeFi protocols.Votes: 0GitHub stars: 13
- Workflow Orchestration PatternsDesign durable workflows with Temporal for distributed systems. Covers workflow vs activity separation, saga patterns, state management, and determinism constraints. Use when building long-running processes, distributed transactions, or microservice orchestration.Votes: 0GitHub stars: 13
- Workflow PatternsUse this skill when implementing tasks according to Conductor's TDD workflow, handling phase checkpoints, managing git commits for tasks, or understanding the verification protocol.Votes: 0GitHub stars: 13
- Workflow Skill CreatorDistills a completed user workflow or interaction into a reusable agent skill. Use when the user asks to turn their workflow, interaction, or multi-step process into a skill, or when they say \"make this a skill\", \"create a skill from what we just did\", \"package this workflow\" or similar. Do not use for creating skills from scratch without an existing workflow (use a generic skill-creator for that).Votes: 0GitHub stars: 13
- Zero Build FrontendZero-build frontend development for static apps, browser extensions, maps, and lightweight data-backed interfaces. Use when deployment must not require a build step.Votes: 0GitHub stars: 13
- Zinc DatabaseQuery the ZINC22 virtual compound library (CartBlanche API, billions of make-on-demand + purchasable molecules). Look up substances by ZINC ID, resolve a SMILES to its ZINC ID (exact match), inspect purchasability/catalogs, and assemble compound sets for docking. Property (MW/logP) filtering is done locally with RDKit. For bioactivity use chembl-database-bioactivity; for approved drugs use drugbank-database-access.Votes: 0GitHub stars: 13