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Claude Skills by FridrichMethod
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- Alphagenome Atlas Website LinksConstructs deep-links and URLs for the AlphaGenome Atlas website. Supports generating single-variant exploration links (1-based chr:pos:ref>alt), genomic locus views (1-based closed chr:start-end), candidate summary tables, and AlphaGenome reference vs. alternate predictions. Use whenever visualizing, exploring, charting, or linking genetic variants and genomic loci on the AlphaGenome Atlas, or when asked to inspect, view, or link predictions for a genomic variant.Votes: 0GitHub stars: 15
- Alphagenome Variant Impact ScoreScore, annotate, and analyze the functional impact of genetic variants using AlphaGenome Variant Impact (AVI) scores. Query variants in chr:pos:ref>alt format, annotate VCF/tabular callsets, perform saturation mutagenesis window scans (1-based closed chr:start-end), and extract GENCODE v46 GTF gene/exon/junction coordinates all via the AlphaGenome Atlas API.Votes: 0GitHub stars: 15
- Architecture Decision RecordsWrite and maintain Architecture Decision Records (ADRs) following best practices for technical decision documentation. Use when documenting significant technical decisions, reviewing past architectural choices, or establishing decision processes.Votes: 0GitHub stars: 15
- Nature Paper CardBuild a structured deep-reading Paper Card for one scientific paper, analysing methods, experiment-to-claim evidence, limitations, and research ideas. Use for 论文精读卡、方法拆解、证据链分析; not full-paper bilingual translation or formal peer review.Votes: 0GitHub stars: 15
- Clinical Decision SupportPrepare and validate research-only clinical decision-support evaluation, evidence-profile, cohort, survival, biomarker/model, privacy, and governance artifacts. Use for aggregate or synthetic research documentation and traceability—not patient care or live clinical operation.Votes: 0GitHub stars: 15
- Clinical ReportsCreate safety-bounded draft structures and run local deterministic checks for clinical case, diagnostic, trial, safety, and aggregate research reports. Use only with synthetic, de-identified, or aggregate inputs and verified source-fact manifests; every output requires qualified review.Votes: 0GitHub stars: 15
- Pptx PostersCreate and audit editable scientific posters in macro-free PowerPoint (.pptx) from author-approved local content and assets. Use when the requested deliverable is a PowerPoint research/conference poster and exact physical, printer, accessibility, provenance, and package-security checks are required.Votes: 0GitHub stars: 15
- Treatment PlansFormat and structurally validate local treatment-plan documentation after clinical decisions have already been supplied and verified by authorized licensed professionals. Use for source traceability, clinician-authored intervention records, goals and checkpoints, shared-decision records, reconciliation handoffs, and release gates—not for clinical decision-making.Votes: 0GitHub stars: 15
- Venue TemplatesPrepare journal manuscripts, conference papers, research posters, and grant documents using venue-specific formatting guidance and bundled LaTeX scaffolds. Use when selecting an official template, checking current page or anonymity rules, adapting academic writing to a venue, or inspecting a submission PDF.Votes: 0GitHub stars: 15
- Nx Workspace PatternsConfigure and optimize Nx monorepo workspaces. Use when setting up Nx, configuring project boundaries, optimizing build caching, or implementing affected commands.Votes: 0GitHub stars: 13
- On Call Handoff PatternsMaster on-call shift handoffs with context transfer, escalation procedures, and documentation. Use this skill when transitioning on-call responsibilities between engineers and ensuring the incoming responder has full situational awareness, when writing a shift summary that captures active incidents, ongoing investigations, and recent changes, when handing off mid-incident so a fresh engineer can take over the incident commander role without losing context, when onboarding a new engineer to th...Votes: 0GitHub stars: 13
- One Way DoorUse this skill when creating new files that represent architectural decisions — data models, infrastructure configs, auth boundaries, API contracts, CI/CD pipelines, or event systems. Flags irreversible decisions and forces a discussion about trade-offs before committing.Votes: 0GitHub stars: 13
- Ontology ExplorerParse, navigate, and query materials science ontology structure (classes, properties, hierarchy). Use when exploring an ontology like CMSO, understanding class relationships, finding properties for a given class, or searching for ontology terms related to a materials science concept. Supports OWL/XML format from the OCDO ecosystem (CMSO, ASMO, CDCO, PODO, PLDO, LDO).Votes: 0GitHub stars: 13
- Ontology MapperMap materials science terms, crystal structures, and sample descriptions to ontology classes and properties. Supports any ontology registered in ontology_registry.json. Use when translating natural-language material descriptions to ontology terms, annotating simulation inputs with ontology metadata, or mapping crystal parameters (space group, Bravais lattice, lattice constants) to standardized ontology representations.Votes: 0GitHub stars: 13
- Ontology ValidatorValidate material sample annotations and data structures against ontology constraints. Use when checking if CMSO annotations are correct, verifying that required properties are present, or validating that object property relationships have consistent domain and range. Catches unknown classes, unknown properties, domain mismatches, and missing required fields.Votes: 0GitHub stars: 13
- Openapi Spec GenerationGenerate and maintain OpenAPI 3.1 specifications from code, design-first specs, and validation patterns. Use when creating API documentation, generating SDKs, or ensuring API contract compliance.Votes: 0GitHub stars: 13
- Opentrons Protocol AgentGenerates executable Python protocols for Opentrons OT-2 and Flex robots from natural language descriptions.Votes: 0GitHub stars: 13
- Organoid Drug Response AgentAI-powered analysis of patient-derived organoid (PDO) drug screening for personalized oncology treatment selection and biomarker discovery.Votes: 0GitHub stars: 13
- Outbreak PipelineEnd-to-end outbreak investigation from pathogen isolates to transmission networks. Orchestrates MLST typing, AMR surveillance, phylodynamic dating, and transmission inference with TransPhylo. Use when investigating disease outbreaks or tracking pathogen transmission chains.Votes: 0GitHub stars: 13
- PacsomaticOperator toolkit for nf-core/pacsomatic matched tumor-normal workflows from BAM inputs. Use this skill when the user needs to validate run inputs, generate pacsomatic-compliant samplesheets, prepare reproducible Nextflow launch artifacts, run locally or submit to schedulers (LSF/Slurm/PBS/SGE), and triage execution failures. Triggers on requests to run pacsomatic, prepare launch commands/scripts, perform dry-run checks, or troubleshoot pipeline startup and scheduler submission errors.Votes: 0GitHub stars: 13
- Page MonitoringWeb page monitoring, change detection, and availability tracking. Use when tracking content changes, detecting when pages go down, monitoring for updates, preserving content before deletion, or generating feeds for pages without RSS. Covers Visualping, ChangeTower, Distill.io, and self-hosted monitoring solutions.Votes: 0GitHub stars: 13
- Pan Cancer Multiomics AgentAI-powered pan-cancer analysis integrating genomic, transcriptomic, proteomic, and epigenomic data for cancer subtyping, driver identification, and cross-cancer pattern discovery.Votes: 0GitHub stars: 13
- PaperzillaChat with your agent about projects, recommendations, and canonical papers in Paperzilla. Use when users ask for recent project recommendations, canonical paper details, markdown-based summaries, recommendation feedback, feed export, or Atom feed URLs.Votes: 0GitHub stars: 13
- Parallel Feature DevelopmentCoordinate parallel feature development with file ownership strategies, conflict avoidance rules, and integration patterns for multi-agent implementation. Use this skill when decomposing a large feature into independent work streams, when two or more agents need to implement different layers of the same system simultaneously, when establishing file ownership to prevent merge conflicts in a shared codebase, when designing interface contracts so parallel implementers can build against each othe...Votes: 0GitHub stars: 13
- Pathogen TypingAssigns isolate identity at the right resolution for the question -- ANI / Mash species triage, 7-locus MLST historical comparability, cgMLST / wgMLST outbreak resolution (chewBBACA, BIGSdb, Ridom SeqSphere, EnteroBase HierCC), in-silico serotyping (SISTR, SeqSero2 for Salmonella; SerotypeFinder for E. coli; Kaptive K/O for Klebsiella; SeroBA for pneumococcus; spa + SCCmec for S. aureus), and lineage callers (TB-Profiler / Mykrobe Coll-Napier barcode for MTBC, Pangolin + Nextclade for SARS-Co...Votes: 0GitHub stars: 13
- Paypal IntegrationIntegrate PayPal payment processing with support for express checkout, subscriptions, and refund management. Use when implementing PayPal payments, processing online transactions, or building e-commerce checkout flows.Votes: 0GitHub stars: 13
- Pci ComplianceImplement PCI DSS compliance requirements for secure handling of payment card data and payment systems. Use when securing payment processing, achieving PCI compliance, or implementing payment card security measures.Votes: 0GitHub stars: 13
- Pdb"Fetch and analyze protein structures from RCSB PDB. Use this skill when: (1) Need to download a structure by PDB ID, (2) Search for similar structures, (3) Prepare target for binder design, (4) Extract specific chains or domains, (5) Get structure metadata.Votes: 0GitHub stars: 13
- Pdx Model Analysis AgentAI-powered analysis of patient-derived xenograft (PDX) models for drug response prediction, translational research, and personalized treatment selection.Votes: 0GitHub stars: 13
- Pharmacogenomics AgentAI-driven pharmacogenomic analysis for precision dosing and adverse event prediction using multi-omics data.Votes: 0GitHub stars: 13
- PhylodynamicsEstimates time-scaled phylogenies, molecular clock rates, effective reproduction number R_e (or R_t), and population dynamics from dated pathogen genomes using TreeTime (maximum-likelihood) and BEAST2 (Bayesian; strict / uncorrelated lognormal / ORC clocks; constant / exponential / Bayesian Skyline / Skygrid / BICEPS / Birth-Death-Skyline / sampled-ancestor BDSKY priors; structured coalescent via MASCOT). Covers root-to-tip clock signal QC via TempEst, date-randomisation tests (Ramsden 2009; ...Votes: 0GitHub stars: 13
- PhylogeneticsBuild and analyze phylogenetic trees using MAFFT (multiple alignment), IQ-TREE 2 (maximum likelihood), and FastTree (fast NJ/ML). Visualize with ETE3 or FigTree. For evolutionary analysis, microbial genomics, viral phylodynamics, protein family analysis, and molecular clock studies.Votes: 0GitHub stars: 13
- Polars DataframesFast in-memory DataFrame with lazy evaluation, parallel execution, Arrow backend. Use for tabular data in RAM (1–100 GB) when pandas is too slow. Expression API: select, filter, group_by, joins, pivots, window. Lazy mode enables predicate/projection pushdown. Reads CSV, Parquet, JSON, Excel, DBs, cloud. Larger-than-RAM: Dask; GPU: cuDF.Votes: 0GitHub stars: 13
- Popeve Variant Predictor AgentAI-powered genetic variant pathogenicity prediction using PopEVE deep learning model for population-aware disease variant identification and rare disease diagnosis.Votes: 0GitHub stars: 13
- PostgresqlUse this skill when designing or reviewing a PostgreSQL-specific schema. Covers best-practices, data types, indexing, constraints, performance patterns, and advanced featuresVotes: 0GitHub stars: 13
- Postmortem WritingWrite effective blameless postmortems with root cause analysis, timelines, and action items. Use when conducting incident reviews, writing postmortem documents, or improving incident response processes.Votes: 0GitHub stars: 13
- Precision Oncology AgentFuse genomic variants, pathology findings, and clinical context to draft evidence-linked therapy options for tumor board review.Votes: 0GitHub stars: 13
- Prime Editing ScreensDesigns and analyzes pooled prime-editor (PE) screens for installing precise genetic variants without bystander confounding. Covers pegRNA design with PRIDICT and PRIDICT2 (Mathis 2023/2024) for predicting per-pegRNA editing efficiency, pegRNA architecture (spacer + scaffold + PBS + RTT), PE2 / PE3 / PE3b / PEmax / PEAR variants, MOSAIC in situ saturation mutagenesis (Hsu JY et al 2024 bioRxiv), the PRIME pooled-screen methodology (Erwood/Doman 2023 Nat Biotechnol 41:885; ~3,699 ClinVar varia...Votes: 0GitHub stars: 13
- Prior Auth CoworkerPrior Auth ReviewVotes: 0GitHub stars: 13
- Production SchedulingCodified expertise for production scheduling, job sequencing, line balancing, changeover optimization, and bottleneck resolution in discrete and batch manufacturing. Informed by production schedulers with 15+ years experience. Includes TOC/drum-buffer-rope, SMED, OEE analysis, disruption response frameworks, and ERP/MES interaction patterns. Use when scheduling production, resolving bottlenecks, optimizing changeovers, responding to disruptions, or balancing manufacturing lines.Votes: 0GitHub stars: 13
- Profile ReportUnified personal genomic profile report — reads a PatientProfile JSON and synthesizes all skill results into a single \"Your Genomic Profile\" document.Votes: 0GitHub stars: 13
- Project MemoryGenerate CLAUDE.md project memory files that transfer institutional knowledge, not obvious information. Use when setting up new journalism projects, onboarding collaborators, or documenting project-specific quirks. Includes templates for editorial tools, event websites, publications, research projects, content pipelines, and digital archives.Votes: 0GitHub stars: 13
- Project RetrospectiveGenerate LESSONS.md retrospective files that capture institutional knowledge, especially failures. Use when closing out journalism projects, investigations, events, or publications. Includes templates for research projects, event post-mortems, editorial tools, and publications.Votes: 0GitHub stars: 13
- Projection PatternsBuild read models and projections from event streams. Use when implementing CQRS read sides, building materialized views, or optimizing query performance in event-sourced systems.Votes: 0GitHub stars: 13
- Prometheus ConfigurationSet up Prometheus for comprehensive metric collection, storage, and monitoring of infrastructure and applications. Use when implementing metrics collection, setting up monitoring infrastructure, or configuring alerting systems.Votes: 0GitHub stars: 13
- Prompt Engineering PatternsMaster advanced prompt engineering techniques to maximize LLM performance, reliability, and controllability in production. Use when optimizing prompts, improving LLM outputs, or designing production prompt templates.Votes: 0GitHub stars: 13
- Prompt OptimizerAnalyze raw prompts, identify intent and gaps, match ECC components (skills/commands/agents/hooks), and output a ready-to-paste optimized prompt. Advisory role only — never executes the task itself. TRIGGER when: user says \"optimize prompt\", \"improve my prompt\", \"how to write a prompt for\", \"help me prompt\", \"rewrite this prompt\", or explicitly asks to enhance prompt quality. Also triggers on Chinese equivalents: \"优化prompt\", \"改进prompt\", \"怎么写prompt\", \"帮我优化这个指令\". DO NOT TRIGGE...Votes: 0GitHub stars: 13
- Protac Design AgentAI-powered PROTAC (Proteolysis Targeting Chimera) design for targeted protein degradation, integrating ternary complex prediction, linker optimization, and ADMET modeling.Votes: 0GitHub stars: 13
- Protein Design Workflow"End-to-end guidance for protein design pipelines. Use this skill when: (1) Starting a new protein design project, (2) Need step-by-step workflow guidance, (3) Understanding the full design pipeline, (4) Planning compute resources and timelines, (5) Integrating multiple design tools.Votes: 0GitHub stars: 13
- Protein Qc"Quality control metrics and filtering thresholds for protein design. Use this skill when: (1) Evaluating design quality for binding, expression, or structure, (2) Setting filtering thresholds for pLDDT, ipTM, PAE, (3) Checking sequence liabilities (cysteines, deamidation, polybasic clusters), (4) Creating multi-stage filtering pipelines, (5) Computing PyRosetta interface metrics (dG, SC, dSASA), (6) Checking biophysical properties (instability, GRAVY, pI), (7) Ranking designs with composite ...Votes: 0GitHub stars: 13