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Claude Skills by FridrichMethod
github.com/FridrichMethod743 skills4 installs957 views
- Protein Structure PredictionPredicts 3D protein structures from amino acid sequences using ESMFold or AlphaFold3 (mock).Votes: 0GitHub stars: 13
- Proteinmpnn"Design protein sequences using ProteinMPNN inverse folding. Use this skill when: (1) Designing sequences for RFdiffusion backbones, (2) Redesigning existing protein sequences, (3) Fixing specific residues while designing others, (4) Optimizing sequences for expression or stability, (5) Multi-state or negative design.Votes: 0GitHub stars: 13
- Prs Net Deep Learning AgentGeometric deep learning-based polygenic risk score prediction using PRS-Net for modeling gene interactions, enhanced disease prediction, and cross-ancestry portability.Votes: 0GitHub stars: 13
- Psychologist Analyst"Analyzes events through psychological lens using cognitive psychology, social psychology, developmental psychology,Votes: 0GitHub stars: 13
- Pubmed DatabaseProgrammatic PubMed access via NCBI E-utilities REST API. Covers Boolean/MeSH queries, field-tagged search, endpoints (ESearch, EFetch, ESummary, EPost, ELink), history server for batches, citation matching, systematic review strategies. Use for biomedical literature search or automated pipelines.Votes: 0GitHub stars: 13
- Pytdc Therapeutics Data CommonsTherapeutics Data Commons (TDC) AI-ready drug discovery datasets. Curated ADME, toxicity, DTI, DDI with scaffold/cold splits, standardized metrics, molecular oracles, and ADMET benchmarks for therapeutic ML and property prediction. For chemical database queries use chembl-database-bioactivity; for featurization use molfeat.Votes: 0GitHub stars: 13
- Python Anti PatternsUse this skill when reviewing Python code for common anti-patterns to avoid. Use as a checklist when reviewing code, before finalizing implementations, or when debugging issues that might stem from known bad practices.Votes: 0GitHub stars: 13
- Python Background JobsPython background job patterns including task queues, workers, and event-driven architecture. Use when implementing async task processing, job queues, long-running operations, or decoupling work from request/response cycles.Votes: 0GitHub stars: 13
- Python ConfigurationPython configuration management via environment variables and typed settings. Use when externalizing config, setting up pydantic-settings, managing secrets, or implementing environment-specific behavior.Votes: 0GitHub stars: 13
- Python Design PatternsPython design patterns including KISS, Separation of Concerns, Single Responsibility, and composition over inheritance. Use this skill when designing a new service or component from scratch and choosing how to layer responsibilities, when refactoring a God class or monolithic function that has grown too large, when deciding whether to add a new abstraction or live with duplication, when evaluating a pull request for structural issues like tight coupling or leaking internal types, when choosin...Votes: 0GitHub stars: 13
- Python Error HandlingPython error handling patterns including input validation, exception hierarchies, and partial failure handling. Use when implementing validation logic, designing exception strategies, handling batch processing failures, or building robust APIs.Votes: 0GitHub stars: 13
- Python ObservabilityPython observability patterns including structured logging, metrics, and distributed tracing. Use when adding logging, implementing metrics collection, setting up tracing, or debugging production systems.Votes: 0GitHub stars: 13
- Python PackagingCreate distributable Python packages with proper project structure, setup.py/pyproject.toml, and publishing to PyPI. Use when packaging Python libraries, creating CLI tools, or distributing Python code.Votes: 0GitHub stars: 13
- Python PipelinePython data processing pipelines with modular architecture. Use when building content processing workflows, implementing dispatcher patterns, integrating Google Sheets/Drive APIs, or creating batch processing systems. Covers patterns from rosen-scraper, image-analyzer, and social-scraper projects.Votes: 0GitHub stars: 13
- Python ResiliencePython resilience patterns including automatic retries, exponential backoff, timeouts, and fault-tolerant decorators. Use when adding retry logic, implementing timeouts, building fault-tolerant services, or handling transient failures.Votes: 0GitHub stars: 13
- Python Resource ManagementPython resource management with context managers, cleanup patterns, and streaming. Use when managing connections, file handles, implementing cleanup logic, or building streaming responses with accumulated state.Votes: 0GitHub stars: 13
- Python Testing PatternsImplement comprehensive testing strategies with pytest, fixtures, mocking, and test-driven development. Use when writing Python tests, setting up test suites, or implementing testing best practices.Votes: 0GitHub stars: 13
- Python Type SafetyPython type safety with type hints, generics, protocols, and strict type checking. Use when adding type annotations, implementing generic classes, defining structural interfaces, or configuring mypy/pyright.Votes: 0GitHub stars: 13
- Quality NonconformanceCodified expertise for quality control, non-conformance investigation, root cause analysis, corrective action, and supplier quality management in regulated manufacturing. Informed by quality engineers with 15+ years experience across FDA, IATF 16949, and AS9100 environments. Includes NCR lifecycle management, CAPA systems, SPC interpretation, and audit methodology. Use when investigating non-conformances, performing root cause analysis, managing CAPAs, interpreting SPC data, or handling suppl...Votes: 0GitHub stars: 13
- Radgpt Radiology ReporterRadiology ReporterVotes: 0GitHub stars: 13
- Radiomics Pathomics Fusion AgentAI-powered multimodal fusion of radiology (CT/MRI/PET) and pathology (H&E/IHC) imaging with clinical and genomic data for comprehensive cancer diagnostics and treatment prediction.Votes: 0GitHub stars: 13
- React ModernizationUpgrade React applications to latest versions, migrate from class components to hooks, and adopt concurrent features. Use when modernizing React codebases, migrating to React Hooks, or upgrading to latest React versions.Votes: 0GitHub stars: 13
- React Native ArchitectureBuild production React Native apps with Expo, navigation, native modules, offline sync, and cross-platform patterns. Use when developing mobile apps, implementing native integrations, or architecting React Native projects.Votes: 0GitHub stars: 13
- React Native DesignMaster React Native styling, navigation, and Reanimated animations for cross-platform mobile development. Use when building React Native apps, implementing navigation patterns, or creating performant animations.Votes: 0GitHub stars: 13
- React State ManagementMaster modern React state management with Redux Toolkit, Zustand, Jotai, and React Query. Use when setting up global state, managing server state, or choosing between state management solutions.Votes: 0GitHub stars: 13
- Regulatory DrafterAutomates the drafting of regulatory documents (e.g., FDA CTD sections) with citation management and audit trails.Votes: 0GitHub stars: 13
- Regulatory DraftingRegulatory Drafting agent for healthcare workflows.Votes: 0GitHub stars: 13
- Research LiteratureResearch Literature agent for healthcare workflows.Votes: 0GitHub stars: 13
- Returns Reverse LogisticsCodified expertise for returns authorization, receipt and inspection, disposition decisions, refund processing, fraud detection, and warranty claims management. Informed by returns operations managers with 15+ years experience. Includes grading frameworks, disposition economics, fraud pattern recognition, and vendor recovery processes. Use when handling product returns, reverse logistics, refund decisions, return fraud detection, or warranty claims.Votes: 0GitHub stars: 13
- Rfdiffusion"Generate protein backbones using RFdiffusion, a diffusion-based generative model for de novo protein structure generation. Use this skill when: (1) Designing binder scaffolds for a target protein, (2) Generating novel protein backbones from scratch, (3) Scaffolding functional motifs into new proteins, (4) Specifying hotspot residues for interface design, (5) Creating symmetric oligomers.Votes: 0GitHub stars: 13
- Risk Metrics CalculationCalculate portfolio risk metrics including VaR, CVaR, Sharpe, Sortino, and drawdown analysis. Use when measuring portfolio risk, implementing risk limits, or building risk monitoring systems.Votes: 0GitHub stars: 13
- Rna Velocity AgentAI-powered RNA velocity analysis for predicting cellular state transitions, differentiation trajectories, and dynamic gene regulation from single-cell RNA sequencing data.Votes: 0GitHub stars: 13
- Rnaseq To DeEnd-to-end RNA-seq workflow from FASTQ files to differential expression results. Covers QC, quantification (Salmon or STAR+featureCounts), and DESeq2 analysis with visualization. Use when running RNA-seq from FASTQ to DE results.Votes: 0GitHub stars: 13
- Rust Async PatternsMaster Rust async programming with Tokio, async traits, error handling, and concurrent patterns. Use when building async Rust applications, implementing concurrent systems, or debugging async code.Votes: 0GitHub stars: 13
- Saga OrchestrationImplement saga patterns for distributed transactions and cross-aggregate workflows. Use this skill when implementing distributed transactions across microservices where 2PC is unavailable, designing compensating actions for failed order workflows that span inventory, payment, and shipping services, building event-driven saga coordinators for travel booking systems that must roll back hotel, flight, and car rental reservations atomically, or debugging stuck saga states in production where comp...Votes: 0GitHub stars: 13
- Sast ConfigurationConfigure Static Application Security Testing (SAST) tools for automated vulnerability detection in application code. Use when setting up security scanning, implementing DevSecOps practices, or automating code vulnerability detection.Votes: 0GitHub stars: 13
- Scfoundation Model AgentUnified agent for leveraging single-cell foundation models (scGPT, scBERT, Geneformer, scFoundation) for cross-species annotation, perturbation prediction, and gene network inference.Votes: 0GitHub stars: 13
- Scholar EvaluationApply the ScholarEval framework to systematically evaluate scholarly and research work. This skill provides structured evaluation methodology based on peer-reviewed research assessment criteria, enabling comprehensive analysis of academic papers, research proposals, literature reviews, and scholarly writing across multiple quality dimensions.Votes: 0GitHub stars: 13
- Scientific Manuscript WritingScientific manuscript writing: IMRAD, citation styles (APA/AMA/Vancouver/IEEE), figures/tables, reporting guidelines (CONSORT/STROBE/PRISMA/ARRIVE), writing principles (clarity/conciseness/accuracy), venue-specific style. For LaTeX see companion assets.Votes: 0GitHub stars: 13
- Scientific ManuscriptHigh-impact scientific manuscript preparation for journals like Nature, Blood, Cell. Use when writing abstracts, introductions, methods, results, discussions, or figure legends. Includes citation management, statistical reporting standards, ICMJE guidelines, and journal-specific formatting for hematology/oncology publications.Votes: 0GitHub stars: 13
- Scientific SlidesScientific presentations for conferences, seminars, thesis defenses, and grant pitches. Slide design, talk structure, timing, data viz for slides, QA. PowerPoint and LaTeX Beamer. For posters use latex-research-posters.Votes: 0GitHub stars: 13
- Scientific WritingCore skill for the deep research and writing tool. Write scientific manuscripts in full paragraphs (never bullet points). Use two-stage process: (1) create section outlines with key points using research-lookup, (2) convert to flowing prose. IMRAD structure, citations (APA/AMA/Vancouver), figures/tables, reporting guidelines (CONSORT/STROBE/PRISMA), for research papers and journal submissions.Votes: 0GitHub stars: 13
- Scikit BioPython library for biology: sequence manipulation (DNA/RNA/protein), pairwise/multiple alignment, phylogenetic trees (NJ, UPGMA), diversity (Shannon, Faith PD, Bray-Curtis, UniFrac), ordination (PCoA, CCA, RDA), stats (PERMANOVA, ANOSIM, Mantel), file I/O (FASTA, FASTQ, Newick, BIOM). Use for microbiome, community ecology, or phylogenetics.Votes: 0GitHub stars: 13
- Scrna QcExecute the MAD-based single-cell RNA-seq QC workflow (scripts + Python API) to filter low-quality cells and emit reports plus filtered AnnData files.Votes: 0GitHub stars: 13
- Seaborn Statistical PlotsStatistical visualization on matplotlib with native pandas support. Auto aggregation, CIs, grouping for distributions (histplot, kdeplot), categorical (boxplot, violinplot), relational (scatterplot, lineplot), regression (regplot, lmplot), matrix (heatmap, clustermap), grids (pairplot, FacetGrid). Use for quick statistical summaries; matplotlib for fine control; plotly for interactive HTML.Votes: 0GitHub stars: 13
- Search StrategyQuery decomposition and multi-source search orchestration. Breaks natural language questions into targeted searches per source, translates queries into source-specific syntax, ranks results by relevance, and handles ambiguity and fallback strategies.Votes: 0GitHub stars: 13
- Secure AuthSecure authentication implementation patterns. Use when implementing user login, registration, password reset, session management, JWT authentication, OAuth, MFA, or passkeys. Provides production-ready patterns aligned with NIST SP 800-63B-4, OWASP 2026 cheat sheets, OAuth 2.1, and WebAuthn L3, with breach-driven lessons.Votes: 0GitHub stars: 13
- Security ChecklistPre-deployment security audit for web applications, organized by OWASP Top 10:2025 categories. Use when reviewing code before shipping, auditing an existing application, or when users mention "security review," "ready to deploy," "going to production," or express concern about vulnerabilities. Covers access control, supply chain, cryptography, injection, auth, integrity, logging, and exception handling.Votes: 0GitHub stars: 13
- Security Requirement ExtractionDerive security requirements from threat models and business context. Use when translating threats into actionable requirements, creating security user stories, or building security test cases.Votes: 0GitHub stars: 13
- Security ReviewUse this skill when adding authentication, handling user input, working with secrets, creating API endpoints, or implementing payment/sensitive features. Provides comprehensive security checklist and patterns.Votes: 0GitHub stars: 13