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Claude Skills by FridrichMethod
github.com/FridrichMethod743 skills4 installs957 views
- Event Store DesignDesign and implement event stores for event-sourced systems. Use when building event sourcing infrastructure, choosing event store technologies, or implementing event persistence patterns.Votes: 0GitHub stars: 13
- Exosome Ev Analysis AgentAI-powered extracellular vesicle and exosome analysis for cancer biomarker discovery, liquid biopsy applications, and intercellular communication profiling.Votes: 0GitHub stars: 13
- Exploratory Data AnalysisMethodology for exploratory data analysis on scientific files. Decision frameworks by data type (tabular, sequence, image, spectral, structural, omics), quality assessment, report generation, format detection across 200+ formats. Use when given a data file for initial exploration or to pick an analysis before a pipeline.Votes: 0GitHub stars: 13
- Fact Check WorkflowStructured fact-checking workflow. Use when verifying claims for publication, rating claims, or setting pre-publication checks.Votes: 0GitHub stars: 13
- Fhir DevelopmentFHIR Development agent for healthcare workflows.Votes: 0GitHub stars: 13
- Fine MappingResolves GWAS associations to candidate causal variants and credible sets via SuSiE, susie_rss, FINEMAP, CAVIAR, DAP-G, PAINTOR, PolyFun, SuSiEx, MultiSuSiE, and FOCUS. Use when narrowing a GWAS lead SNP to a 95 percent credible set, choosing between in-sample and reference LD, calibrating non-sparse loci with SuSiE-inf or FINEMAP-inf, integrating functional priors via PolyFun, fine-mapping across ancestries with SuSiEx, diagnosing LD mismatch via estimate_s_rss and kriging_rss, handling HLA ...Votes: 0GitHub stars: 13
- Foia RequestsFOIA and public records workflows. Use when drafting requests, tracking submissions, checking exemptions, or appealing denials.Votes: 0GitHub stars: 13
- Foldseek"Structure similarity search with Foldseek. Use this skill when: (1) Finding similar structures in PDB/AFDB databases, (2) Structural homology search, (3) Database queries by 3D structure, (4) Finding remote homologs not detected by sequence, (5) Clustering structures by similarity.Votes: 0GitHub stars: 13
- Foldseek Structural SearchPerforms 3D structural searches of proteins against various databases (PDB, AlphaFold, CATH, MGnify, etc.) using the Foldseek API. Use ONLY when the user provides a physical 3D coordinate file (.cif, .mmcif, or .pdb) and wants to find structurally similar proteins. Do NOT use if the user only provides a protein sequence, gene name, or UniProt ID.Votes: 0GitHub stars: 13
- FootprintingDetect transcription factor binding footprints in ATAC-seq using TOBIAS, HINT-ATAC, Wellington, or scprinter. Use when identifying bound TF sites within accessible regions, correcting Tn5 insertion bias before footprinting, choosing between cleavage-based and aggregate-based footprinters, or comparing differential TF activity between conditions.Votes: 0GitHub stars: 13
- FoundationsFrames the phasing/imputation pipeline before any tool runs: phasing and imputation are one Li-Stephens copying HMM (recombination is the transition, mutation the emission, the genetic map and Ne set the rates), imputation's honest output is a dosage with a self-estimated quality (INFO/R2/DR2) not a hard genotype, and the stages are ordered and each fails silently (QC, align build and strand to the panel, phase, impute per chromosome, filter by INFO/R2 plus a MAF floor, carry dosages to GWAS)...Votes: 0GitHub stars: 13
- Fragment AnalysisPredict restriction digest fragment sizes and gel patterns using Biopython Bio.Restriction. Computes fragment lengths and sequences for single and double digests on linear or circular DNA, and interprets them against an agarose gel. Use when predicting the fragments from a digest, planning a diagnostic digest to verify a clone, or matching observed gel bands to an expected pattern.Votes: 0GitHub stars: 13
- Free Apis CatalogCurated free APIs with verified free-tier limits. Use when suggesting APIs or finding free weather, news, finance, or sports data.Votes: 0GitHub stars: 13
- Gatk CnvCall copy number variants with the GATK best-practices workflows — the somatic CNV pipeline (CollectReadCounts, DenoiseReadCounts with tangent normalization, ModelSegments, CallCopyRatioSegments) and the germline GATK-gCNV pipeline (DetermineGermlineContigPloidy, GermlineCNVCaller cohort/case mode, PostprocessGermlineCNVCalls). Covers panel-of-normals construction, AnnotateIntervals/FilterIntervals, allelic-count integration, and QS-based filtering. Use when integrating CNV calling into a GAT...Votes: 0GitHub stars: 13
- Gdpr Data HandlingImplement GDPR-compliant data handling with consent management, data subject rights, and privacy by design. Use when building systems that process EU personal data, implementing privacy controls, or conducting GDPR compliance reviews.Votes: 0GitHub stars: 13
- Gene Panel Design AgentAI-powered design of targeted gene panels for clinical and research applications including cancer diagnostics, pharmacogenomics, and rare disease testing.Votes: 0GitHub stars: 13
- Genome Browser TracksGenerate genome browser visualizations using pyGenomeTracks or IGV batch scripting for publication figures. Use when creating publication figures of genomic regions with multiple data tracks.Votes: 0GitHub stars: 13
- Geo DataQuery and download from NCBI Gene Expression Omnibus (GEO) and EMBL-EBI's BioStudies/ArrayExpress mirror. Use when finding expression datasets, navigating SuperSeries vs SubSeries, choosing between series-matrix (submitter-normalized) and raw supplementary files, downloading via GEOparse (Python) or GEOquery (R/Bioconductor), linking GEO to SRA for raw reads, or distinguishing GSE/GSM/GPL/GDS record types. Encodes the SuperSeries trap, the series-matrix normalization-trust caveat, GEOmetadb d...Votes: 0GitHub stars: 13
- Geopandas GeospatialGeospatial vector analysis extending pandas. Read/write spatial formats (Shapefile, GeoJSON, GeoPackage, Parquet, PostGIS), CRS handling, geometric ops (buffer, simplify, centroid, affine), spatial analysis (joins, overlays, dissolve, clipping, distance), visualization (choropleth, interactive maps, basemaps). Use for spatial joins, overlays, CRS transforms, area/distance, maps.Votes: 0GitHub stars: 13
- Germinal"De novo antibody and nanobody (VHH) design with Germinal. Use this skill when: (1) Designing epitope-targeted nanobodies or scFvs, (2) Needing CDR design on a fixed framework, (3) Working on antibody-format binders rather than miniproteins.Votes: 0GitHub stars: 13
- Git Advanced WorkflowsMaster advanced Git workflows including rebasing, cherry-picking, bisect, worktrees, and reflog to maintain clean history and recover from any situation. Use when managing complex Git histories, collaborating on feature branches, or troubleshooting repository issues.Votes: 0GitHub stars: 13
- Github Actions TemplatesCreate production-ready GitHub Actions workflows for automated testing, building, and deploying applications. Use when setting up CI/CD with GitHub Actions, automating development workflows, or creating reusable workflow templates.Votes: 0GitHub stars: 13
- Gitlab Ci PatternsBuild GitLab CI/CD pipelines with multi-stage workflows, caching, and distributed runners for scalable automation. Use when implementing GitLab CI/CD, optimizing pipeline performance, or setting up automated testing and deployment.Votes: 0GitHub stars: 13
- Gnomad FrequenciesQueries gnomAD v4 (807k samples), v3, v2.1.1, and constraint metrics with grpmax FAF95, bottleneck-group exclusion, LOEUF interpretation, SV/CNV/mtDNA catalogs, and Whiffin max-credible-AF framework. Use when filtering rare variants, applying ACMG BS1/BA1, ranking genes by LoF intolerance, or selecting between v2 (GRCh37 + chrX/Y constraint) and v4 (GRCh38 + 807k samples).Votes: 0GitHub stars: 13
- Gnomad DatabaseQuery the Genome Aggregation Database (gnomAD). Use when determining the rarity or allele frequency of specific genetic variants, retrieving gene constraint metrics (pLI, LOEUF) to assess loss-of-function intolerance, finding variants in a genomic region or gene, or querying structural variants. Don't use for analyzing individual patient genomes, tracking somatic mutations in cancer (use COSMIC), or requesting raw sequencing reads (use ENA).Votes: 0GitHub stars: 13
- Go Concurrency PatternsMaster Go concurrency with goroutines, channels, sync primitives, and context. Use when building concurrent Go applications, implementing worker pools, or debugging race conditions.Votes: 0GitHub stars: 13
- Godot Gdscript PatternsMaster Godot 4 GDScript patterns including signals, scenes, state machines, and optimization. Use when building Godot games, implementing game systems, or learning GDScript best practices.Votes: 0GitHub stars: 13
- Gtex DatabaseUse when you want to retrieve quantitative RNA expression data and variant eQTL information from the GTEx (Genotype-Tissue Expression) Project across 54 non-diseased tissue sites.Votes: 0GitHub stars: 13
- Helm Chart ScaffoldingDesign, organize, and manage Helm charts for templating and packaging Kubernetes applications with reusable configurations. Use when creating Helm charts, packaging Kubernetes applications, or implementing templated deployments.Votes: 0GitHub stars: 13
- Hemoglobinopathy Analysis AgentAI-powered analysis of hemoglobin disorders including sickle cell disease, thalassemias, and variant hemoglobins using HPLC, electrophoresis, and molecular data.Votes: 0GitHub stars: 13
- Hermes TweetInstall and operate Hermes Tweet, a Hermes Agent plugin for X/Twitter research, timeline reading, tweet analysis, and approval-gated private or state-changing operations. Use this skill when installing Hermes Tweet, researching X/Twitter accounts, monitoring launch signals, investigating mentions, auditing giveaways, or preparing gated X operations. Use proactively when a Hermes Agent workflow needs current X/Twitter context. Requires XQUIK_API_KEY for read and action tools.Votes: 0GitHub stars: 13
- Hgt DetectionDetect horizontal gene transfer (HGT / LGT) using compositional methods (GC%, codon usage, tetranucleotide z-scores via SIGI-HMM, AlienHunter, IslandViewer 4, IslandPath-DIMOB), phylogenetic-incongruence methods (AvP, HGTphyloDetect, ALE / GeneRax / AleRax reconciliation, RANGER-DTL), and BLAST-distribution methods (HGTector v2, DarkHorse, Alien Index). Use when screening prokaryote genomes for genomic islands and HGT events, distinguishing HGT from incomplete lineage sorting / differential g...Votes: 0GitHub stars: 13
- Hit CallingCross-method decision tree for calling hits in pooled CRISPR screens. Catalogs statistical models (MAGeCK RRA, MAGeCK MLE, BAGEL2, drugZ, JACKS, Chronos, CERES), experimental designs each is built for, failure modes outside design domain, reconciliation when methods disagree, multiple-testing and effect-size thresholds, the order of operations (count -> QC -> CN-correct -> hit-call -> validate), the second-best-sgRNA conservative rule, and consensus-hit strategy. Use when choosing among MAGeC...Votes: 0GitHub stars: 13
- Hla TypingCalls HLA class I and class II alleles at 2/4/6/8-field resolution from WGS/WES/RNA-seq/long-read data using OptiType, HLA-LA, T1K, Polysolver, HLA-HD, arcasHLA, StarPhase, or HIBAG imputation. Use when typing for HSCT, solid-organ transplant, neoantigen prediction, PGx screening (B*57:01, B*15:02, etc.), or disease-association studies, with reconciliation across tools and IPD-IMGT/HLA version mismatch handling.Votes: 0GitHub stars: 13
- Hrd Analysis AgentAI-powered homologous recombination deficiency (HRD) analysis for PARP inhibitor response prediction using genomic scarring signatures and BRCA pathway assessment.Votes: 0GitHub stars: 13
- Human Protein Atlas DatabaseUse when you want to retrieve semi-quantitative protein expression and spatial localisation data from the Human Protein Atlas (HPA).Votes: 0GitHub stars: 13
- Hybrid Cloud NetworkingConfigure secure, high-performance connectivity between on-premises infrastructure and cloud platforms using VPN and dedicated connections. Use when building hybrid cloud architectures, connecting data centers to cloud, or implementing secure cross-premises networking.Votes: 0GitHub stars: 13
- Hybrid Search ImplementationCombine vector and keyword search for improved retrieval. Use when implementing RAG systems, building search engines, or when neither approach alone provides sufficient recall.Votes: 0GitHub stars: 13
- Immune Checkpoint Combination AgentAI-powered analysis for predicting optimal immune checkpoint inhibitor combinations based on tumor microenvironment, biomarkers, and molecular profiling.Votes: 0GitHub stars: 13
- Incident Runbook TemplatesCreate structured incident response runbooks with step-by-step procedures, escalation paths, and recovery actions. Use this skill when building a service outage runbook for a payment processing system; creating database incident procedures covering connection pool exhaustion, replication lag, and disk space alerts; onboarding new on-call engineers who need step-by-step recovery guides written for a 3 AM brain; or standardizing escalation matrices across multiple engineering teams.Votes: 0GitHub stars: 13
- Interaction DatabasesQuery protein-protein and gene interaction databases (STRING, BioGRID, IntAct, SIGNOR, Reactome, HuRI, HuMAP, OmniPath, ConsensusPathDB, DIP). Use when building PPI networks, choosing between physical vs functional vs genetic interactions, signed/directed vs undirected, high-throughput vs curated, picking confidence thresholds, aggregating across resources, or navigating license constraints. Encodes the database decision matrix, STRING v12 channel semantics, OmniPath as meta-database, SIGNOR ...Votes: 0GitHub stars: 13
- Interaction DesignDesign and implement microinteractions, motion design, transitions, and user feedback patterns. Use when adding polish to UI interactions, implementing loading states, or creating delightful user experiences.Votes: 0GitHub stars: 13
- Interpro DatabaseIdentify domains, families, and sites in proteins; find all proteins in a family or sharing a domain; explore species distribution for a domain; annotate genomes with protein families and GO terms. InterPro combines 14 databases (e.g., Pfam, CDD) into one searchable resource. InterPro-N significantly expands annotation and sequence coverage with deep learning. Includes domain architecture (IDA) search.Votes: 0GitHub stars: 13
- Interview PrepInterview preparation and recording-consent law. Use for research, question frameworks, one-party or all-party consent rules.Votes: 0GitHub stars: 13
- Interview TranscriptionTranscription, recording management, and quote extraction. Use when processing audio/video or generating timestamped transcripts.Votes: 0GitHub stars: 13
- Inventory Demand PlanningCodified expertise for demand forecasting, safety stock optimization, replenishment planning, and promotional lift estimation at multi-location retailers. Informed by demand planners with 15+ years experience managing hundreds of SKUs. Includes forecasting method selection, ABC/XYZ analysis, seasonal transition management, and vendor negotiation frameworks. Use when forecasting demand, setting safety stock, planning replenishment, managing promotions, or optimizing inventory levels.Votes: 0GitHub stars: 13
- Ipsae"Binder design ranking using ipSAE (interprotein Score from Aligned Errors). Use this skill when: (1) Ranking binder designs for experimental testing, (2) Filtering BindCraft or RFdiffusion outputs, (3) Comparing AF2/AF3/Boltz predictions, (4) Predicting binding success rates, (5) Need better ranking than ipTM or iPAE.Votes: 0GitHub stars: 13
- Iso 13485 CertificationPrepare and structurally review ISO 13485 QMS scope, controlled documentation, and local evidence manifests. Use for ISO 13485 certification-readiness documentation or for separating related FDA QMSR, MDSAP, and EU MDR/IVDR evidence boundaries; not for legal applicability, compliance, or certification decisions.Votes: 0GitHub stars: 13
- Isoform SwitchingAnalyzes differential transcript usage (DTU) and isoform switches with functional consequence prediction (NMD via 50nt rule, ORF disruption, protein domain loss/gain, signal peptide changes, IDR alterations, coding-potential shifts). Tools include IsoformSwitchAnalyzeR v2 (auto-selects satuRn for >5 reps else DEXSeq), the manual DRIMSeq -> DEXSeq/satuRn -> stageR DTU pipeline, and fishpond/swish for inferential-uncertainty-aware DTE. Distinguishes DTU from DGE and DTE; integrates external ann...Votes: 0GitHub stars: 13
- Istio Traffic ManagementConfigure Istio traffic management including routing, load balancing, circuit breakers, and canary deployments. Use when implementing service mesh traffic policies, progressive delivery, or resilience patterns.Votes: 0GitHub stars: 13