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Claude Skills by FridrichMethod
github.com/FridrichMethod743 skills4 installs957 views
- Cell Free ExpressionGuidance for cell-free protein synthesis (CFPS) optimization. Use when: (1) Planning CFPS experiments, (2) Troubleshooting low yield or aggregation, (3) Optimizing DNA template design for CFPS, (4) Expressing difficult proteins (disulfide-rich, toxic, membrane).Votes: 0GitHub stars: 13
- Cellagent AnnotationCell taggerVotes: 0GitHub stars: 13
- Cellchat Cell CommunicationInfer and visualize intercellular communication from scRNA-seq with CellChat (R). Build CellChat from Seurat/counts → subset CellChatDB ligand-receptor pairs → over-expressed genes per group → communication probabilities → pathway signaling → network centrality (senders/receivers/influencers) → chord/heatmap/bubble plots → cross-condition compare. Human, mouse. Use liana for pure-Python.Votes: 0GitHub stars: 13
- Cellfree Rna AgentAI-powered cell-free RNA analysis from liquid biopsy for cancer detection, tissue-of-origin identification, and non-invasive transcriptomic profiling.Votes: 0GitHub stars: 13
- Cellular Senescence AgentAI-powered analysis of cellular senescence for aging research, cancer therapy response, and senolytic drug development.Votes: 0GitHub stars: 13
- Chai"Structure prediction using Chai-1, a foundation model for molecular structure. Use this skill when: (1) Predicting protein-protein complex structures, (2) Validating designed binders, (3) Predicting protein-ligand complexes, (4) Using the Chai API for high-throughput prediction, (5) Need an alternative to AlphaFold2.Votes: 0GitHub stars: 13
- Changelog AutomationAutomate changelog generation from commits, PRs, and releases following Keep a Changelog format. Use when setting up release workflows, generating release notes, or standardizing commit conventions.Votes: 0GitHub stars: 13
- Chatehr Clinician AssistantEHR Chat AssistantVotes: 0GitHub stars: 13
- Chematagent Drug DiscoveryChemical Lab AgentVotes: 0GitHub stars: 13
- Chembl DatabaseQuery the ChEMBL database for bioactive molecules, drug targets, bioactivity data, approved drugs, and chemical structures. Use when the user asks about compounds, targets, IC50/Ki values, drug mechanisms, or structure searches.Votes: 0GitHub stars: 13
- Chemcrow Drug DiscoveryAn LLM chemistry agent with expert-designed tools for organic synthesis, drug discovery, and materials design.Votes: 0GitHub stars: 13
- Chemical Property LookupCompute RDKit-driven molecular properties (MW, logP, TPSA, QED, Lipinski) for a SMILES string to support downstream drug discovery tools.Votes: 0GitHub stars: 13
- Chemist Analyst"Analyzes events through chemistry lens using molecular structure, reaction mechanisms, thermodynamics,Votes: 0GitHub stars: 13
- Chemistry AgentAutonomous chemical synthesis & analysisVotes: 0GitHub stars: 13
- Chip Clonal Hematopoiesis AgentAI-powered clonal hematopoiesis of indeterminate potential (CHIP) detection, risk stratification, and cardiovascular/malignancy risk prediction using genomic and clinical data.Votes: 0GitHub stars: 13
- Chipseq QcAssesses ChIP-seq quality across antibody specificity, fragmentation, enrichment, replicate concordance, and library complexity. Computes FRiP, NSC/RSC (phantompeakqualtools), library complexity (NRF/PBC1/PBC2), deepTools plotFingerprint (JS distance, AUC, synthetic JS), ChIPQC, IDR with ENCODE Nself/Nt rules, and detects hyper-ChIPable artifacts. Use when validating an antibody, diagnosing failed peak calls, deciding whether to proceed with downstream analysis, grading against ENCODE thresho...Votes: 0GitHub stars: 13
- Chipseq VisualizationVisualizes ChIP-seq data using deepTools (computeMatrix, plotHeatmap, plotProfile, bamCoverage, bamCompare), pyGenomeTracks (modern INI-driven track plots), Gviz (R browser-style), EnrichedHeatmap (ComplexHeatmap-based), ChIPseeker tag heatmaps, and IGV batch screenshots. Handles bigWig normalization choices (CPM, BPM, RPGC, spike-in scaled), bamCompare operations (log2 ratio, subtract) with SES scaling, k-means clustering of heatmaps for biological subgrouping, and spike-in-scaled tracks for...Votes: 0GitHub stars: 13
- Chromosomal Instability AgentAI-powered analysis of chromosomal instability (CIN) signatures for cancer prognosis, immunotherapy response prediction, and therapeutic vulnerability identification.Votes: 0GitHub stars: 13
- Claims AppealsClaims Appeals agent for healthcare workflows.Votes: 0GitHub stars: 13
- Claude Api"Reference for the Claude API / Anthropic SDK — model ids, pricing, params, streaming, tool use, MCP, agents, caching, token counting, model migration.Votes: 0GitHub stars: 13
- Clinical Nlp ExtractorExtracts medical entities (Diseases, Medications, Procedures) from unstructured clinical text using regex and simple rules (or LLM wrappers).Votes: 0GitHub stars: 13
- Clinical Note SummarizationStructure raw clinical notes into SOAP-format summaries with explicit contradictions, missing data, and ICD-linked assessments using the provided prompt + usage script.Votes: 0GitHub stars: 13
- Clinical Trials DatabaseQuery ClinicalTrials.gov via APIv2. Use when you want to search for trials by condition, drug, location, status, or phase; retrieve trial details by NCT ID; check eligibility/inclusion criteria; count trials across conditions or time periods; identify a sponsor's trial portfolio; find recruiting trials for patient matching.Votes: 0GitHub stars: 13
- Clinvar LookupQueries ClinVar for variant pathogenicity classifications, ClinGen VCEP curations, and somatic-vs-germline interpretations via REST API, weekly VCF, or bulk XML. Use when determining clinical significance, triangulating conflicting interpretations, or aggregating evidence against the ACMG/AMP framework with ClinGen SVI specifications.Votes: 0GitHub stars: 13
- Clinvar DatabaseUse when needing clinical significance, pathogenicity classifications (e.g., Pathogenic, Benign, VUS), clinical evidence rationales, or finding \"hard positive\" benchmark controls for human genomic variants.Votes: 0GitHub stars: 13
- Clip AlignmentAlign preprocessed CLIP-seq reads (eCLIP, iCLIP, iCLIP2, PAR-CLIP) to genome with STAR or bowtie2 using crosslink-preserving parameters, choosing between unique-mapper-only and multi-mapper-aware alignment for repeat-binding RBPs, deciding STAR vs HISAT2 memory trade-offs, and applying ENCODE-compatible filters. Use when turning preprocessed CLIP FASTQ into a deduplicated, MAPQ-filtered BAM ready for peak calling or crosslink-site detection.Votes: 0GitHub stars: 13
- Clip Motif AnalysisDiscover RBP binding motifs from CLIP-seq peaks or single-nucleotide crosslink sites using HOMER, MEME/STREME, kpLogo, mCross (CL-position-registered motifs), PEKA (positional k-mer enrichment), RBPamp (affinity), and RNA Bind-n-Seq (RBNS) cross-validation. Use when characterizing RBP sequence specificity, registering motifs to crosslink positions, validating in vivo CLIP motifs against in vitro RBNS Kd, reconciling motif disagreements across tools, or correcting for the uracil crosslinking b...Votes: 0GitHub stars: 13
- Clip Peak CallingCall protein-RNA binding sites from CLIP-seq BAM with CLIPper, PureCLIP, Skipper, Piranha, omniCLIP, CTK, CLAM, or Paraclu. Use when choosing between coverage-based, HMM-based, beta-binomial window-based, and crosslink-site-based peak callers; applying ENCODE eCLIP thresholds (log2 IP/SMInput >= 3, -log10 p >= 3); deciding when SMInput is mandatory; or reconciling peak-set discordance between callers for the same RBP.Votes: 0GitHub stars: 13
- Clip PreprocessingPreprocess CLIP-seq reads (eCLIP, iCLIP, iCLIP2, iCLIP3, irCLIP, PAR-CLIP, FLASH) with protocol-specific UMI extraction, adapter trimming, length filtering, and post-alignment PCR-duplicate collapse. Use when raw CLIP FASTQ must be turned into deduplicated, crosslink-preserving BAM input for peak calling; choosing between two-pass and single-pass adapter trimming; deciding minimum read length; or mapping UMI patterns to specific eCLIP/iCLIP/iCLIP2/iCLIP3 library preps.Votes: 0GitHub stars: 13
- Cnv AnnotationAnnotate copy number variant segments with overlapping genes, dosage-sensitivity scores, cancer driver databases, population frequencies, and clinical-variant content. Covers bedtools/pybedtools interval intersection, AnnotSV comprehensive annotation and ranking, ClinGen haploinsufficiency/triplosensitivity scoring, gnomAD-SV/DGV frequency filtering, COSMIC Cancer Gene Census, and ClinVar overlap. Use when interpreting which genes a CNV affects, distinguishing the driver gene of a focal event...Votes: 0GitHub stars: 13
- Cnv Caller AgentAI-enhanced copy number variation calling and analysis from sequencing data for cancer genomics, constitutional CNV detection, and chromosomal aberration characterization.Votes: 0GitHub stars: 13
- Cnv PipelineOrchestrates the copy-number pipeline from BAM to segmented, integer-called, annotated CNVs, forking on germline-vs-somatic - CNVkit (somatic exome/panel: coverage -> assay-matched reference/PoN -> fix -> segment -> purity/ploidy-aware call), GATK gCNV (germline rare-CNV cohort), and allele-specific callers (ASCAT/FACETS/PURPLE) for purity/ploidy. Use when committing the build + target/access BED + PoN once (assay-matched), building the reference from normals BEFORE segmenting, fitting purity...Votes: 0GitHub stars: 13
- Cnv VisualizationVisualize copy number profiles, segments, allele-specific tracks, and cohort patterns from CNVkit, GATK, ASCAT, FACETS, Sequenza, and other callers. Covers genome-wide and per-chromosome log2 scatter plots, B-allele-frequency/minor-allele-fraction tracks, ideograms, cohort heatmaps, circos views, and caller-native plots. Use when creating publication CNV figures, choosing which plot answers a given question, diagnosing a wrong diploid baseline visually, displaying loss of heterozygosity, or d...Votes: 0GitHub stars: 13
- Cnvkit AnalysisDetect somatic and germline copy number variants from targeted, exome, and whole-genome sequencing with CNVkit, a read-depth caller that combines on-target and off-target (antitarget) coverage. Covers panel-of-normals construction, flat-reference tumor-only calling, hybrid/amplicon/WGS modes, CBS vs HMM segmentation selection, purity-aware integer calling, and reconciliation against GATK and allele-specific callers. Use when calling CNVs from hybrid-capture panels or exomes, deciding whether ...Votes: 0GitHub stars: 13
- Coagulation Thrombosis AgentAI-powered analysis of coagulation disorders, thrombosis risk prediction, anticoagulation management, and platelet function assessment using machine learning.Votes: 0GitHub stars: 13
- Coding StandardsUniversal coding standards, best practices, and patterns for TypeScript, JavaScript, React, and Node.js development.Votes: 0GitHub stars: 13
- Colocalization AnalysisTest whether two or more traits share a causal variant at a locus using Bayesian colocalization (coloc.abf, coloc.susie, HyPrColoc, moloc, eCAVIAR, SMR/HEIDI, PWCoCo, SharePro). Use when integrating GWAS with eQTL/sQTL/pQTL/mQTL, distinguishing shared causal variants from LD-driven coincidence, handling allelic heterogeneity, choosing between single-causal vs multi-causal methods, picking PP.H4 thresholds, running sensitivity over p12, or harmonising summary statistics for colocalization.Votes: 0GitHub stars: 13
- Color PalettesSelect colormaps and qualitative palettes for scientific figures using perceptual-uniformity, color-vision-deficiency safety, and luminance-monotonicity criteria. Covers Crameri scientific colormaps, viridis/cividis/magma, Okabe-Ito categorical, ColorBrewer, and the rainbow/jet critique. Use when choosing palettes for heatmaps, scatter, networks, or any encoding where color carries quantitative or categorical meaning.Votes: 0GitHub stars: 13
- Compbioagent ExplorerscRNA-seq ExplorerVotes: 0GitHub stars: 13
- Competitive LandscapeAnalyze competition, identify differentiation opportunities, and develop winning market positioning strategies using Porter's Five Forces, Blue Ocean Strategy, and positioning maps. Use this skill when evaluating competitors, assessing market positioning, identifying sustainable competitive advantages, or preparing competitive strategy analysis for a startup or investor pitch.Votes: 0GitHub stars: 13
- ComposerSystematic writing framework for philosophy and interdisciplinary academic papers from optimized outline to submission-ready manuscript. Use when users want to: (1) write a paper from a detailed outline, (2) ensure quality control during writing, (3) maintain consistency across chapters, (4) prepare a submission-ready manuscript, or (5) systematically execute a planned paper. Triggered by phrases like 'write the paper from this outline,' 'compose the full manuscript,' 'execute the outline,' o...Votes: 0GitHub stars: 13
- Computational Pathology AgentAnalyze Whole Slide Images (WSI) for digital pathology, including tissue segmentation and feature extraction.Votes: 0GitHub stars: 13
- Content AccessLegal methods for paywalled and geo-blocked content. Use for paywalls, academic papers, or open access via Unpaywall.Votes: 0GitHub stars: 13
- Context Driven DevelopmentCreates and maintains project context artifacts (product.md, tech-stack.md, workflow.md, tracks.md) in a `conductor/` directory. Scaffolds new projects from scratch, extracts context from existing codebases, validates artifact consistency before implementation, and synchronizes documents as the project evolves. Use when setting up a project, creating or updating product docs, managing a tech stack file, defining development workflows, tracking work units, onboarding to an existing codebase, o...Votes: 0GitHub stars: 13
- Cost OptimizationOptimize cloud costs across AWS, Azure, GCP, and OCI through resource rightsizing, tagging strategies, reserved instances, and spending analysis. Use when reducing cloud expenses, analyzing infrastructure costs, or implementing cost governance policies.Votes: 0GitHub stars: 13
- Cqrs ImplementationImplement Command Query Responsibility Segregation for scalable architectures. Use when separating read and write models, optimizing query performance, or building event-sourced systems.Votes: 0GitHub stars: 13
- CredentialsInstructions for handling API keys and credentials safely, verifying their presence, and prompting the user to add them if missing using a safe protocol.Votes: 0GitHub stars: 13
- Crisis CommunicationsCrisis communication and rapid-response workflows. Use when covering breaking news or coordinating fast fact-checking on deadline.Votes: 0GitHub stars: 13
- Crispr Guide DesignGuide foundryVotes: 0GitHub stars: 13
- Crispr Offtarget PredictorPredicts potential off-target sites for a given sgRNA sequence using mismatch analysis.Votes: 0GitHub stars: 13